Generative AI is revolutionizing Drug-Target Interaction (DTI) prediction by automating drug design, improving binding accuracy, and accelerating discovery timelines. It replaces manual, trial-and-error methods with predictive, end-to-end pipelines. While challenges like interpretability and data quality persist, real-world case studies show its promise. GenAI is set to reshape pharma by making drug discovery faster, smarter, and more scalable.